Feynman as an amateur

Then I guess I have to tell about the time I tried with Hildegarde Lamfrom to discover whether peas could use the same ribosomes as bacteria. The question was whether the ribosomes of bacteria can manufacture the proteins of humans or other organisms, She had just developed a scheme for getting the ribosomes out of peas and giving them messenger RNA so that they would make pea proteins. We realized that a very dramatic and important question was whether ribosomes from bacteria, when given the peas' messenger RNA, would make pea protein or bacteria protein. It was to be a very dramatic and fundamental experiment.

Hildegarde said, "I'll need a lot of ribosomes from bacteria."

Meselson and I had extracted enormous quantities of ribosomes from E. coli for some other experiment. I said, "Hell, I'll just give you the ribosomes we've got. We have plenty of them in my refrigerator at the lab."

It would have been a fantastic and vital discovery if I had been a good biologist. But I wasn't a good biologist. We had a good idea, a good experiment, the right equipment, but I screwed it up: I gave her infected ribosomes - the grossest possible error that you could make in an experiment like that. My ribosomes had been in the refrigerator for almost a month, and had become contaminated with some other living things. Had I prepared those ribosomes promptly over again and given them to her in a serious and careful way, with everything under control, that experiment would have worked, and we would have been the first to demonstrate the uniformity of life: the machinery of making proteins, the ribosomes, is the same in every creature. We were there at the right place, we were doing the right things, but I was doing things as an amateur - stupid and sloppy.

And here we have the largest of the insidious fears I have about this project: that as I fumble around trying to build this amazing piece of equipment, I will miss the boat entirely, despite being right next to it. (The boat, that is.)

Optimism, dear boy, optimism! And sustained hard work.

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